Ontology highlight
ABSTRACT:
SUBMITTER: van der Vliet A
PROVIDER: S-EPMC5900994 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
van der Vliet Albert A Danyal Karamatullah K Heppner David E DE
British journal of pharmacology 20180315 9
NADPH oxidases (NOXs) represent a family of enzymes that mediate regulated cellular production of reactive oxygen species (ROS) and play various functional roles in physiology. Among the NOX family, the dual oxidases DUOX1 and DUOX2 are prominently expressed in epithelial cell types at mucosal surfaces and have therefore been considered to have important roles in innate host defence pathways. Recent studies have revealed important insights into the host defence mechanisms of DUOX enzymes, which ...[more]