The association of polymorphisms in miRNAs with nonsmall cell lung cancer in a Han Chinese population.

ABSTRACT:

Background

MicroRNAs (miRNAs) have been demonstrated to play important roles in cancer progression. Recently, studies have revealed that polymorphisms in miRNAs might be associated with cancer susceptibility.

Materials and methods

In the current study, we investigated the associations of single nucleotide polymorphisms (SNPs) in miRNAs (rs11134527 in pri-miR-218-2, rs74693964 in pri-miR-145, rs6062251 in pri-miR-133a-2, and rs4705343 in pri-miR-143) with nonsmall cell lung cancer (NSCLC) in a Han population from Yunnan Province, Southwest China using a binary logistic regression analysis. A total of 452 patients with NSCLC and 452 healthy individuals were recruited for polymorphism genotyping using the TaqMan assay.

Results

Our results show

SUBMITTER: Li C 

PROVIDER: S-EPMC5901134 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature