Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells.

ABSTRACT:

Purpose

Plasmonic nanostructure-mediated photothermal therapy (PTT) is a promising alternative therapy for the treatment of skin cancer and other diseases. However, the insufficient efficiency of PTT at irradiation levels tolerable to tissues and the limited biodegradability of nanomaterials are still crucial challenges. In this study, a novel nanosystem for PTT based on liposome-nanoparticle assemblies (LNAs) was established.

Materials and methods

Thermal-sensitive liposomes (TSLs) encapsulating cantharidin (CTD) were coated with gold nanoparticles (GNPs) and used in near-infrared (NIR) illumination-triggered PTT and thermally induced disruption on A431 cells.

Results

The coated GNPs disintegrated into small particles of 5-6 nm after disruption of TSLs, allowing thei

SUBMITTER: Wang S 

PROVIDER: S-EPMC5901154 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature