Terminal spreading depolarization and electrical silence in death of human cerebral cortex.

ABSTRACT: OBJECTIVE:Restoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could help predict the time available for resuscitation until irreversible damage and advance development of interventions that prolong this span. Experimentally, injury to central neurons begins only with anoxic depolarization. This potentially reversible, spreading wave typically starts 2 to 5 minutes after the onset of severe ischemia, marking the onset of a toxic intraneuronal change that eventually results in irreversible injury. METHODS:To investigate this in the human brain, we performed recordings with either subdural electrode strips (n = 4) or intraparenchymal electrode arrays (n = 5) in patients with deva

SUBMITTER: Dreier JP 

PROVIDER: S-EPMC5901399 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature