Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study.

ABSTRACT:

Background

Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not.

Objectives

To assess whether prolonged exposure to Cr-tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr-allergic individuals.

Method

Ten Cr-allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr-tanned and a Cr-free leather bracelet over a period of 3 weeks, for 12 h per day. Cr deposited on the skin from the bracelets was measured in the controls, and the diphenylcarbazide test for Cr(VI) and extraction tests for Cr(III) and Cr(VI) were conducted for the different leathers.

Results

SUBMITTER: Hedberg YS 

PROVIDER: S-EPMC5901407 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature