Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy.

ABSTRACT: Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell-derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, and to show reduced immunogenicity as compared to other synthetic nanoparticles. Although initial clinical trials are ongoing, the use of EVs for therapeutic applications may be limited due to undesired off-target activity and potential "dilution effects" upon systemic administration which may affect their ability to reach their target tissues. To fully exploit their therapeutic potential, EVs are embedded into implantable biomaterials designed to achieve local delivery of therapeutics taking advantage

SUBMITTER: Fuhrmann G 

PROVIDER: S-EPMC5901706 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature