Parental Age and Risk of Infant Leukaemia: A Pooled Analysis.

ABSTRACT:

Background

Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL.

Methods

We evaluated the relationship between parental age and IL in a case-control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981-20

SUBMITTER: Marcotte EL 

PROVIDER: S-EPMC5901723 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature