Benefits of varenicline vs. bupropion for smoking cessation: a Bayesian analysis of the interaction of reward sensitivity and treatment.

ABSTRACT:

Rationale

We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome.

Objectives

This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cessation.

Methods

Prior to treatment randomization, smokers (N = 180) in a placebo-controlled trial using bupropion and varenicline completed event-related potential recording (late positive potential, LPP) while viewing pleasant (P), cigarette (C)-related, and other pictures. We used Bayesian models to estimate the probability of interaction between treatment and the LPP for both efficacy and comparative effectiveness analyses.

Results

Efficacy analy

SUBMITTER: Cinciripini PM 

PROVIDER: S-EPMC5901731 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature