The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.

ABSTRACT:

Objective

Previous studies have characterized the hepatoprotective and anti-inflammatory properties of oleanolic acid (OA). This study aimed to investigate the molecular mechanisms of OA hepatoprotection in concanavalin A- (ConA-) induced acute liver injury.

Materials and methods

ConA (20 mg/kg) was intravenously injected to induce acute liver injury in Balb/C mice. OA pretreatment (20, 40, and 80 mg/kg) was administered subcutaneously once daily for 3 consecutive days prior to treatment with ConA; 2, 8, and 24 h after ConA injection, the levels of serum liver enzymes and the histopathology of major factors and inflammatory cytokines were determined.

Results

OA reduced the release of serum liver enzymes and inflammatory factors and prevented ConA mediated damage to th

SUBMITTER: Wang W 

PROVIDER: S-EPMC5901823 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature