Referral bias in ALS epidemiological studies.

ABSTRACT:

Background

Despite concerns about the representativeness of patients from ALS tertiary centers as compared to the ALS general population, the extent of referral bias in clinical studies remains largely unknown. Using data from EURALS consortium we aimed to assess nature, extent and impact of referral bias.

Methods

Four European ALS population-based registries located in Ireland, Piedmont, Puglia, Italy, and Limousin, France, covering 50 million person-years, participated. Demographic and clinic characteristics of ALS patients diagnosed in tertiary referral centers were contrasted with the whole ALS populations enrolled in registries in the same geographical areas.

Results

Patients referred to ALS centers were younger (with difference ranging from 1.1 years to 2.4 year

SUBMITTER: Logroscino G 

PROVIDER: S-EPMC5901916 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature