Probing the modulated formation of gold nanoparticles-beta-lactoglobulin corona complexes and their applications.

ABSTRACT: Understanding the interactions between proteins and nanoparticles (NPs) along with the underlying structural and dynamic information is of utmost importance to exploit nanotechnology for biomedical applications. Upon adsorption onto a NP surface, proteins form a well-organized layer, termed the corona, that dictates the identity of the NP-protein complex and governs its biological pathways. Given its high biological relevance, in-depth molecular investigations and applications of NPs-protein corona complexes are still scarce, especially since different proteins form unique corona patterns, making identification of the biomolecular motifs at the interface critical. In this work, we provide molecular insights and structural characterizations of the bio-nano interface of a popular food-based

SUBMITTER: Yang J 

PROVIDER: S-EPMC5901966 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature