Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a.

ABSTRACT: We previously reported using statins was correlated with improved metastasis-free survival in aggressive breast cancer. The purpose of this study was to examine the effect of statins on metastatic colonization by triple-negative breast cancer (TNBC) cells. TNBC cell lines were treated with simvastatin and then studied for cell cycle progression and proliferation in vitro, and metastasis formation in vivo, following injection of statin-treated cells. Reverse-phase protein assay (RPPA) analysis was performed on statin-treated and control breast cancer cells. RNA interference targeting FOXO3a was used to measure the impact of simvastatin on FOXO3a-expressing cells. The prognostic value of FOXO3a mRNA expression was examined in eight public breast cancer gene expression datasets including 1479

SUBMITTER: Wolfe AR 

PROVIDER: S-EPMC5901982 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature