Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases.

ABSTRACT: RNA molecules are essential and fine regulators of important biological processes. Their role is well documented also in the endocrine system, both in physiological and pathological conditions. Increasing interest is arising about the function and the importance of noncoding RNAs shuttled by extracellular vesicles (EVs). In fact, EV membrane protects nucleic acids from enzyme degradation. Nowadays, the research on EVs and their cargoes, as well as their biological functions, faces the lack of standardization in EV purification. Here, the main techniques for EV isolation are discussed and compared for their advantages and vulnerabilities. Despite the possible discrepancy due to methodological variability, EVs and their RNA content are reported to be key mediators of intercellular communicat

SUBMITTER: Pomatto MAC 

PROVIDER: S-EPMC5902008 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature