Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez Herrera KN
PROVIDER: S-EPMC5902027 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cell reports 20180201 8
Sirtuin 3 (SIRT3) is a NAD<sup>+</sup>-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss. Azaserine, a glutamine analog, was the top compound that inhibited growth and proliferation of cells lacking SIRT3. Using stable isotope tracing of glutamine, we observed ...[more]