Heart Rate Variability and Its Relation to Chronic Kidney Disease: Results From the PREVEND Study.

ABSTRACT: OBJECTIVE:In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes. METHODS:In the population-based Prevention of REnal and Vascular ENdstage Disease study, renal outcomes (CKD, estimated glomerular filtration rate [eGFR], urinary albumin) were measured at baseline and three consecutive examinations. HRV measures (among which SDNN [standard deviation of normal-to-normal RR intervals]) were calculated from time series of beat-to-beat pulse wave recordings at baseline. The lowest (risk) quartile was compared with the upper three quartiles combined, in multivariable survival and linear mixed-effects

SUBMITTER: Thio CHL 

PROVIDER: S-EPMC5902130 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature