Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.

ABSTRACT: Rab molecular switches are key players in defining membrane identity and regulating intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity, Rab-family members acquired particular features that allow them to perform specific cellular functions. The overall fold and local sequence conservations enable them to utilize a common machinery for prenylation and recycling; while individual Rab structural differences determine interactions with specific partners such as GEFs, GAPs and effector proteins. These interactions orchestrate the spatiotemporal regulation of Rab localization and their turning ON and OFF, leading to tightly controlled Rab-specific functionalities such as membrane composition modifications, recruitment of molecular motors for intra

SUBMITTER: Pylypenko O 

PROVIDER: S-EPMC5902227 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature