Association between glutathione peroxidase 1 codon 198 variant and the occurrence of breast cancer in Rwanda.

ABSTRACT:

Background

Glutathione peroxidase 1 gene (GPX1) is one of the antioxidant enzyme that remove the reactive oxygen species in a continuous process. Since the identification of a well-characterized functional polymorphism named p.Pro198Leu (rs1050450 C>T) in GPX1 gene, abundant studies have evaluated the association between p.Pro198Leu polymorphism and tumor risk in diverse population. But, the available results related to breast cancer are conflicting and absent in Africa. The present case-control study was planned to assess the presence of GPX1 Pro198Leu polymorphism in Rwanda population to determine whether it is associated with the risk of developing breast cancer.

Methods

Genomic DNA from peripheral blood leukocytes of 41 patients with breast cancer and 42 healthy controls

SUBMITTER: Habyarimana T 

PROVIDER: S-EPMC5902397 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature