The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.

ABSTRACT: T lymphocyte homeostatic proliferation, driven by the engagement of T cell antigen receptor with self-peptide/major histocompatibility complexes, and signaling through the common γ-chain-containing cytokine receptors, is critical for the maintenance of the T cell compartment and is regulated by the Fas death receptor (Fas, CD95). In the absence of Fas, Fas-deficient lymphoproliferation spontaneous mutation (lpr) mice accumulate homeostatically expanded T cells. The functional consequences of sequential rounds of homeostatic expansion are not well defined. We thus examined the gene expression profiles of murine wild-type and Fas-deficient lpr CD8⁺ T cell subsets that have undergone different amounts of homeostatic proliferation as defined by their level of CD44 expression, and th

SUBMITTER: Fortner KA 

PROVIDER: S-EPMC5902411 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature