Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells.

ABSTRACT: Type 1 diabetes (T1D) is mediated by destruction of pancreatic β cells by autoantigen-specific CD4⁺ and CD8⁺ T cells, thus the ideal solution for T1D is the restoration of immune tolerance to β cell antigens. We demonstrate the ability of carboxylated 500 nm biodegradable poly(lactide-co-glycolide) (PLG) nanoparticles PLG nanoparticles (either surface coupled with or encapsulating the cognate diabetogenic peptides) to rapidly and efficiently restore tolerance in NOD.SCID recipients of both activated diabetogenic CD4⁺ BDC2.5 chromagranin A-specific and CD8⁺ NY8.3 islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific TCR transgenic T cells in an antigen-specific manner. Further, initiation and maintenance of Ag-PLG

SUBMITTER: Prasad S 

PROVIDER: S-EPMC5902637 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature