Comparing NMR and X-ray protein structure: Lindemann-like parameters and NMR disorder.

ABSTRACT: Disordered protein chains and segments are fast becoming a major pathway for our understanding of biological function, especially in more evolved species. However, the standard definition of disordered residues: the inability to constrain them in X-ray derived structures, is not easily applied to NMR derived structures. We carry out a statistical comparison between proteins whose structure was resolved using NMR and using X-ray protocols. We start by establishing a connection between these two protocols for obtaining protein structure. We find a close statistical correspondence between NMR and X-ray structures if fluctuations inherent to the NMR protocol are taken into account. Intuitively this tends to lend support to the validity of both NMR and X-ray protocols in deriving biomolecular m

SUBMITTER: Faraggi E 

PROVIDER: S-EPMC5902664 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature