Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.

ABSTRACT: Renal blood flow is regulated by the myogenic response (MR) and tubuloglomerular feedback (TGF). Both mechanisms function to buffer not only steady pressure perturbations but also transient ones. In this study, we develop two models of renal autoregulation-a comprehensive model and a simplified model-and use them to analyze the individual contributions of MR and TGF in buffering transient pressure perturbations. Both models represent a single nephron of a rat kidney together with the associated vasculature. The comprehensive model includes detailed representation of the vascular properties and cellular processes. In contrast, the simplified model represents a minimal set of key processes. To assess the degree to which fluctuations in renal perfusion pressure at different frequencies are at

SUBMITTER: Sgouralis I 

PROVIDER: S-EPMC5902684 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature