A survey of functional genomic variation in domesticated chickens.

ABSTRACT:

Background

Deleterious genetic variation can increase in frequency as a result of mutations, genetic drift, and genetic hitchhiking. Although individual effects are often small, the cumulative effect of deleterious genetic variation can impact population fitness substantially. In this study, we examined the genome of commercial purebred chicken lines for deleterious and functional variations, combining genotype and whole-genome sequence data.

Results

We analysed over 22,000 animals that were genotyped on a 60 K SNP chip from four purebred lines (two white egg and two brown egg layer lines) and two crossbred lines. We identified 79 haplotypes that showed a significant deficit in homozygous carriers. This deficit was assumed to stem from haplotypes that potentially harbour let

SUBMITTER: Derks MFL 

PROVIDER: S-EPMC5902831 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature