Application of the automated haematology analyzer XN-30 in an experimental rodent model of malaria.

ABSTRACT: BACKGROUND:The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automated haematology analyzer XN-30 was developed for detection of infected red blood cells (iRBCs) in human blood samples and measurement of their parasitaemia in approximately 1 min through flow cytometry analysis. Additionally, the analyzer simultaneously measured other haematological parameters in these samples. It is inferred that the analyzer would also allow easy and rapid measurement of parasitaemia in mice and provide important clues on the mouse haematological state durin

SUBMITTER: Tougan T 

PROVIDER: S-EPMC5902832 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature