Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data.

ABSTRACT:

Background

The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug resistance remains a substantial concern in many low and middle-income countries. The Q151M and T69 insertion (T69i) resistance mutations in the viral reverse transcriptase gene can reduce susceptibility to all nucleoside/tide analogue reverse transcriptase inhibitors, motivating the present study to investigate the risk factors and outcomes associated with these mutations.

Methods

We considered all data in the UK HIV Drug Resistance Database for blood samples obtained in the period 1997-2014. Where available, treatment history and patient outcomes were obtained through linkage to the UK Collaborative HIV Cohort study. A matched ca

SUBMITTER: Stirrup OT 

PROVIDER: S-EPMC5902836 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature