TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis.

ABSTRACT:

Background

Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis, more rational targets are needed. Toll-like receptors (TLRs) recognize specific motifs on invading pathogens and initiate the innate inflammatory response. We reported that TLR4 contributes to the robust inflammation which is a hallmark of Bacillus cereus endophthalmitis. To identify novel, targetable host inflammatory factors in this disease, we performed microarray analysis to detect TLR4-dependent changes to the retinal transcriptome during B. cereus endophthalmitis.

Results

C57BL/6 J and TLR4^-/- mouse eyes were infected w

SUBMITTER: Coburn PS 

PROVIDER: S-EPMC5902844 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature