Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue.

ABSTRACT: The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF. Our analysis considered the development of DHF in three different perspectives: (a) as a consequence of primary DENV infection, (b) following secondary DENV infection with a

SUBMITTER: Gupta S 

PROVIDER: S-EPMC5902865 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature