Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.

ABSTRACT:

Background

Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the bacterial adhesion and virulence. However the extent of genetic variation in S. aureus sdrD gene within isolates from healthy carriers are not known. The aim of this study was to evaluate allelic variation of the sdrD gene among S. aureus from healthy nasal carriers.

Results

The sdrD A region from 48 S. aureus isolates from healthy carriers were analysed and classified into seven variants. Variations in the sdrD A region were concentrated in the N2 and N3 subdomains. Sequence analysis of the entire sdrD gene of representative isolates revealed variations i

SUBMITTER: Ajayi C 

PROVIDER: S-EPMC5902956 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature