Does information from ClinicalTrials.gov increase transparency and reduce bias? Results from a five-report case series.

ABSTRACT: BACKGROUND:We investigated whether information in ClinicalTrials.gov would impact the conclusions of five ongoing systematic reviews. METHOD:We considered five reviews that included 495 studies total. Each review team conducted a search of ClinicalTrials.gov up to the date of the review's last literature search, screened the records using the review's eligibility criteria, extracted information, and assessed risk of bias and applicability. Each team then evaluated the impact of the evidence found in ClinicalTrials.gov on the conclusions in the review. RESULTS:Across the five reviews, the number of studies that had both a registry record and a publication varied widely, from none in one review to 43% of all studies identified in another. Among the studies with both a record and publication,

SUBMITTER: Adam GP 

PROVIDER: S-EPMC5902969 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature