The impact of genome editing on the introduction of monogenic traits in livestock.

ABSTRACT:

Background

Genome editing technologies provide new tools for genetic improvement and have the potential to become the next game changer in animal and plant breeding. The aim of this study was to investigate how genome editing in combination with genomic selection can accelerate the introduction of a monogenic trait in a livestock population as compared to genomic selection alone.

Methods

A breeding population was simulated under genomic selection for a polygenic trait. After reaching Bulmer equilibrium, the selection objective was to increase the allele frequency of a monogenic trait, with or without genome editing, in addition to improving the polygenic trait. Scenarios were compared for time to fixation of the desired allele, selection response for the polygenic trait, and

SUBMITTER: Bastiaansen JWM 

PROVIDER: S-EPMC5902981 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature