Retention Esophagitis as a Significant Clinical Predictor of Progression to Esophageal Cancer in Achalasia.

ABSTRACT: BACKGROUND/AIMS:Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and histologically altered squamous hyperplasia. We aimed to identify the clinical features of RE associated with achalasia and to clarify the clinical definition of RE in achalasia as a precancerous lesion identified by analyzing biomarker expressions. METHODS:From 2006 to 2015, we retrospectively reviewed 37 patients with achalasia without previous treatment. Among them, 21 patients had diagnostic findings of RE (RE+) and 16 patients had no diagnostic findings of RE (RE-). Immunohistochemical staining of p53, p16, and Ki-67 was performed on the endoscopic biopsy tissues from the patients wit

SUBMITTER: Kim H 

PROVIDER: S-EPMC5903079 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature