The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia.

ABSTRACT:

Introduction

The mechanism by which metabolic syndrome occurs in schizophrenia is not completely known; however, previous work suggests that changes in DNA methylation may be involved which is further influenced by sex. Within this study, the DNA methylome was profiled to identify altered methylation associated with metabolic syndrome in a schizophrenia population on atypical antipsychotics.

Methods

Peripheral blood from schizophrenia subjects was utilized for DNA methylation analyses. Discovery analyses (n = 96) were performed using an epigenome-wide analysis on the Illumina HumanMethylation450K BeadChip based on metabolic syndrome diagnosis. A secondary discovery analysis was conducted based on sex. The top hits from the discovery analyses were assessed in an additi

SUBMITTER: Burghardt KJ 

PROVIDER: S-EPMC5903198 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature