Surface micropattern reduces colonization and medical device-associated infections.

ABSTRACT:

Purpose

Surface microtopography offers a promising approach for infection control. The goal of this study was to provide evidence that micropatterned surfaces significantly reduce the potential risk of medical device-associated infections.

Methodology

Micropatterned and smooth surfaces were challenged in vitro against the colonization and transference of two representative bacterial pathogens - Staphylococcus aureus and Pseudomonas aeruginosa. A percutaneous rat model was used to assess the effectiveness of the micropattern against device-associated S. aureus infections. After the percutaneous insertion of silicone rods into (healthy or immunocompromised) rats, their backs were inoculated with S. aureus. The bacterial burdens were determined in tissues under the rods and in

SUBMITTER: Xu B 

PROVIDER: S-EPMC5903250 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature