Common sequence variants associated with coronary artery disease correlate with the extent of coronary atherosclerosis.

ABSTRACT:

Objective

Single-nucleotide polymorphisms predisposing to coronary artery disease (CAD) have been shown to predict cardiovascular risk in healthy individuals when combined into a genetic risk score (GRS). We examined whether the cumulative burden of known genetic risk variants associated with risk of CAD influences the development and progression of coronary atherosclerosis.

Approach and results

We investigated the combined effects of all known CAD variants in a cross-sectional study of 8622 Icelandic patients with angiographically significant CAD (≥ 50% diameter stenosis). We constructed a GRS based on 50 CAD variants and tested for association with the number of diseased coronary arteries on angiography. In models adjusted for traditional cardiovascular risk factors, the G

SUBMITTER: Bjornsson E 

PROVIDER: S-EPMC5903266 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature