Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.

ABSTRACT: BACKGROUND:Invasive lobular breast tumors display unique reproductive risk factor profiles. Lobular tumors are predominantly Luminal A subtype, and it is unclear whether reported risk factor associations are independent of molecular subtype. METHODS:Polytomous logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between risk factors and histologic subtype [ductal (n = 2,856), lobular (n = 326), and mixed ductal-lobular (n = 473)] in the Carolina Breast Cancer Study (1993-2013). Three-marker immunohistochemical clinical subtypes were defined as Luminal A (ER+ or PR+/HER2-), Luminal B (ER+ or PR+/HER2+), Triple Negative (ER-/PR-/HER2-), and HER2+ (ER-/PR-/HER2+). RESULTS:In case-case analyses compared to ductal, lobular tumors

SUBMITTER: Williams LA 

PROVIDER: S-EPMC5903274 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature