Synapse-specific astrocyte gating of amygdala-related behavior.

ABSTRACT: The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A₁ adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A_2A

SUBMITTER: Martin-Fernandez M 

PROVIDER: S-EPMC5903286 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature