Investigating Plasma Amino Acids for Differentiating Individuals with Autism Spectrum Disorder and Typically Developing Peers.

ABSTRACT:

Background

Plasma amino acid measurements have been extensively investigated in individuals with autism spectrum disorder (ASD). Results thus far have been inconclusive as studies generally disagree on which amino acids are different in individuals with ASD versus their typically developing (TD) peers, due in part to methodological limitations of several studies.

Method

This paper investigates plasma amino acids in children and adults with ASD using data from Arizona State University's Comprehensive Nutritional and Dietary Intervention Study. Measurements from 64 individuals with ASD and 49 TD controls were analyzed using univariate and multivariate statistical techniques.

Results

Univariate analysis indicated increased median levels of glutamate (+21%, p=0.014

SUBMITTER: Vargason T 

PROVIDER: S-EPMC5903290 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature