Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease.

ABSTRACT:

Introduction

Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels of TFF predict the progression of CKD remains to be elucidated.

Methods

We determined the TFF levels using peptide-specific ELISA in spot urine samples and performed a prospective cohort study. The association between the levels of urine TFFs and other urine biomarkers as well as the renal prognosis was analyzed in 216 CKD patients (mean age: 53.7 years, 47.7% female, 56.9% with chronic glomerulonephritis, and mean eGFR: 58.5 ml/min/1.73 m²).

Results

The urine TFF1 and TFF3 levels significantly increased with the progression of CKD stages, but not the urine TFF2 levels. The TFF1 and TFF3 peptide levels

SUBMITTER: Yamanari T 

PROVIDER: S-EPMC5903307 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature