Adolescent Tuning of Association Cortex in Human Structural Brain Networks.

ABSTRACT: Motivated by prior data on local cortical shrinkage and intracortical myelination, we predicted age-related changes in topological organization of cortical structural networks during adolescence. We estimated structural correlation from magnetic resonance imaging measures of cortical thickness at 308 regions in a sample of N = 297 healthy participants, aged 14-24 years. We used a novel sliding-window analysis to measure age-related changes in network attributes globally, locally and in the context of several community partitions of the network. We found that the strength of structural correlation generally decreased as a function of age. Association cortical regions demonstrated a sharp decrease in nodal degree (hubness) from 14 years, reaching a minimum at approximately 19 years, and then

SUBMITTER: Vasa F 

PROVIDER: S-EPMC5903415 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature