Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.

ABSTRACT:

Background

Overexpression of p16 is associated with improved outcomes among patients with oropharyngeal carcinoma. However, its role in the outcomes of patients with nasopharyngeal cancer (NPC) remains unclear.

Methods

Eighty-six patients with NPC treated at MD Anderson Cancer Center from 2000 to 2014 were identified. Epstein-Barr virus (EBV) and human papillomavirus (HPV) status were determined by in situ hybridization (ISH) and p16 by immunohistochemical staining.

Results

EBV positivity was associated with extended overall survival (OS; median, 95.0 vs 44.9 months; p < .004), progression-free survival (PFS; median, 80.4 vs 28.1 months; p < .013), and locoregional control (median, 104.4 vs 65.5 months; p < .043). In patients with EBV-positive tumors, p16 overexpressi

SUBMITTER: Jiang W 

PROVIDER: S-EPMC5903429 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature