SAMe-TT₂R₂ predicts quality of anticoagulation in patients with acute venous thromboembolism: The MAQI² experience.

ABSTRACT: A high SAMe-TT₂R₂ score predicted poor warfarin control and adverse events among atrial fibrillation patients. However, the SAMe-TT₂R₂ score has not been well validated in venous thromboembolism (VTE) patients. A cohort of 1943 warfarin-treated patients with acute VTE was analyzed to correlate the SAMe-TT₂R₂ score with time in therapeutic range (TTR) and clinical adverse events. A TTR <60% was more frequent among patients with a high (>2) versus low (0-1) SAMe-TT₂R₂ score (63.4% vs 52.3%, p<0.0001). A high SAMe-TT₂R₂ score (>2) correlated with increased overall adverse events (7.9 vs 4.5 overall adverse events/100 patient years, p=0.002), driven primarily by increased recurrent VTE

SUBMITTER: Kataruka A 

PROVIDER: S-EPMC5903431 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature