Liver-specific Ldb1 deletion results in enhanced liver cancer development.

ABSTRACT:

Background & aims

LIM-domain-binding (Ldb) proteins have been demonstrated to be essential not only to key embryonic developmental processes but also to carcinogenesis. We have previously demonstrated Ldb1 to be of high biological and developmental relevance, as a targeted deletion of the Ldb1 gene in mice results in an embryonic lethal and pleiotropic phenotype.

Methods

We have now established a liver-specific Ldb1 knock out to investigate the role of Ldb1 in carcinogenesis, in particular in hepatocellular carcinoma (HCC) development, in vivo.

Results

These mice demonstrated a significantly enhanced growth of liver cancer by means of tumor size and number, advocating for an essential role of Ldb1 in HCC development. In addition, proliferation and resistance against a

SUBMITTER: Teufel A 

PROVIDER: S-EPMC5903435 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature