Antimicrobial peptides alter early immune response to influenza A virus infection in C57BL/6 mice.

ABSTRACT: Influenza is a disease of the respiratory system caused by single stranded RNA viruses with varying genotypes. Immunopathogenesis to influenza viruses differs based on virus strain, dose, and mouse strain used in laboratory models. Although effective mucosal immune defenses are important in early host defense against influenza, information on the kinetics of these immune defense mechanisms during the course of influenza infection is limited. We investigated changes to antimicrobial peptides and primary innate immune cells at early time points after infection and compared these variables between two prominent H1N1 influenza A virus (IAV) strains, A/CA/04/2009 and A/PR/08/1934 in C57BL/6 mice. Alveolar and parenchymal macrophage ratios were altered after IAV infection and pro-inflammatory cy

SUBMITTER: LeMessurier KS 

PROVIDER: S-EPMC5903439 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature