Difunctional bacteriophage conjugated with photosensitizers for Candida albicans-targeting photodynamic inactivation.

ABSTRACT:

Background

Candida albicans is the most prevalent fungal pathogen of the human microbiota, causing infections ranging from superficial infections of the skin to life-threatening systemic infections. Due to the increasing occurrence of antibiotic-resistant C. albicans strains, new approaches to control this pathogen are needed. Photodynamic inactivation is an emerging alternative to treat infections based on the interactions between visible light and photosensitisers, in which pheophorbide a (PPA) is a chlorophyll-based photosensitizer that could induce cell death after light irradiation. Due to PPA's phototoxicity and low efficiency, the main challenge is to implement photosensitizer cell targeting and attacking.

Methods

In this study, PPA was conjugated with J

SUBMITTER: Dong S 

PROVIDER: S-EPMC5903486 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature