Distinctive variation in the U3R region of the 5' Long Terminal Repeat from diverse HIV-1 strains.

ABSTRACT: Functional mapping of the 5'LTR has shown that the U3 and the R regions (U3R) contain a cluster of regulatory elements involved in the control of HIV-1 transcription and expression. As the HIV-1 genome is characterized by extensive variability, here we aimed to describe mutations in the U3R from various HIV-1 clades and CRFs in order to highlight strain specific differences that may impact the biological properties of diverse HIV-1 strains. To achieve our purpose, the U3R sequence of plasma derived virus belonging to different clades (A1, B, C, D, F2) and recombinants (CRF02_AG, CRF01_AE and CRF22_01A1) was obtained using Illumina technology. Overall, the R region was very well conserved among and across different strains, while in the U3 region the average inter-strains nucleotide dissimi

SUBMITTER: Mbondji-Wonje C 

PROVIDER: S-EPMC5903597 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature