A new model of wheezing severity in young children using the validated ISAAC wheezing module: A latent variable approach with validation in independent cohorts.

ABSTRACT:

Background

The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations. More precise measurement approaches could improve testing of etiological theories of wheezing illness.

Methods

We evaluated a continuous latent variable model of pediatric wheezing severity based on four IS

SUBMITTER: Brunwasser SM 

PROVIDER: S-EPMC5903664 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature