Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2^/TIS21 via downregulating cytoplasmic nucleolin expression.

ABSTRACT: To understand the regulation of Helicobacter pylori (H. pylori)-associated gastric carcinogenesis, we examined the effect of B-cell translocation gene 2 (BTG2) expression on the biological activity of Tipα, an oncoprotein secreted from H. pylori. BTG2, the human ortholog of mouse TIS21 (BTG2^/TIS21), has been reported to be a primary response gene that is transiently expressed in response to various stimulations. Here, we report that BTG2 is constitutively expressed in the mucous epithelium and parietal cells of the gastric gland in the stomach. Expression was increased in the mucous epithelium following H. pylori infection in contrast to its loss in human gastric adenocarcinoma. Indeed, adenoviral transduction of BTG2^/TIS21 significantly inhibited Tipα activity in MKN

SUBMITTER: Devanand P 

PROVIDER: S-EPMC5903828 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature