Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions.

ABSTRACT: The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity and type 2 diabetes (T2D). Recently, Akkermansia muciniphila has been reported as a beneficial bacterium that reduces gut barrier disruption and insulin resistance. Here we evaluated the role of A. muciniphila-derived extracellular vesicles (AmEVs) in the regulation of gut permeability. We found that there are more AmEVs in the fecal samples of healthy controls compared with those of patients with T2D. In addition, AmEV administration enhanced tight junction function, reduced body weight gain and improved glucose tolerance in high-fat diet (HFD)-induced diabetic mice. To test t

SUBMITTER: Chelakkot C 

PROVIDER: S-EPMC5903829 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature