Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients.

ABSTRACT:

Background

Accumulating evidence has suggested a relationship between calcium-sensing receptor (CASR) polymorphisms and cancer risk in different types of cancer; however, the findings from epidemiologic studies have been conflicting. The purpose of this meta-analysis was to assess the clinical susceptibility of CASR polymorphisms in cancer patients.

Materials and methods

This study systematically searched MEDLINE and EMBASE databases for eligible articles through March 2017. The strength of association was expressed as odds ratio and 95% CI. Publication bias, heterogeneity, sensitivity analysis, and subgroup analyses were also examined.

Results

Fourteen related case-control studies were finally identified to be included in the present analysis. The poole

SUBMITTER: Huang H 

PROVIDER: S-EPMC5903842 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature