Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

ABSTRACT: Susceptibility and protection against human autoimmune diseases, including type I diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human leukocyte antigen (HLA) alleles. However, the mechanisms underpinning such HLA-mediated effects on self-tolerance remain unclear. Here we investigate the molecular mechanism of Goodpasture disease, an HLA-linked autoimmune renal disorder characterized by an immunodominant CD4⁺ T-cell self-epitope derived from the α3 chain of type IV collagen (α3_135-145). While HLA-DR15 confers a markedly increased disease risk, the protective HLA-DR1 allele is dominantly protective in trans with HLA-DR15 (ref. 2). We show that autoreactive α3_135-145-specific T cells expand in patients with Goodpasture di

SUBMITTER: Ooi JD 

PROVIDER: S-EPMC5903850 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature