Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior.

ABSTRACT: The neuronal RNA-binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD-mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuD_OE ). When this set was further limited to genes in the knowledgebase of addiction-related genes database (KARG) that contains predicted HuD-binding sites in their 3' untranslated regions (3'UTRs), we found that HuD regulates networks that have been associated with addiction-like behavior. Th

SUBMITTER: Oliver RJ 

PROVIDER: S-EPMC5903947 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature